Paul Gladen
Specialization
Organic Chemistry
Synthesis
Natural Products
Research Interests
We develop new strategies and methods for making complex molecules starting from simple, commercially available materials. Our current focus is towards synthesis of the chaetoxanthones, a small family of natural products which have shown sub-micromolar activity against malaria.
Education
PhD Indiana University
BA Chemistry, St. Olaf College
Courses Taught
Chemistry 116: General Chemistry II Lab
Chemistry 220: Organic Chemistry I Lecture and Lab
Chemistry 221: Organic Chemistry II Lecture and Lab
Chemistry 430: Advanced Organic Chemistry Lecture
Publications
*Lennon, A. C., Tallen, S. C., Dabire, S. W., Quach, N. H., Gladen, P. T. Total Synthesis of (±)-Chaetoxanthone B. Tetrahedron Letters, 2021, 82, 153390. https://doi.org/10.1016/j.tetlet.2021.153390
Williams, D. R., Gladen, P. T., Patnaik, S. Studies toward norzoanthamine: Ireland–Claisen rearrangements of α,β-unsaturated esters in a stereocontrolled synthesis of trans-fused 2-cyclohexen-1-ones. Tetrahedron, 2021, 95, 132354. https://doi.org/10.1016/j.tet.2021.132354
Chaheine, C. M., Song, C. J., Gladen, P. T., Romo, D. Enantioselective Michael-Proton Transfer-Lactamization for Pyroglutamic Acid Derivatives: Synthesis of Dimethyl-(S,E)-5-oxo-3-styryl-1-tosylpyrrolidine-2,2-dicarboxylate. Organic Synthesis, 2021, 98, 194–226. https://doi.org/10.15227/orgsyn.098.0194
Chaheine, C. M., Gladen, P. T., Abbasov, M. E., Romo, D. Enantioselective, Organocatalytic Strategy for the Oxazolomycin Core: Formal Synthesis of (+)-Neooxazolomycin. Organic Letters, 2020, 22, 9282–9286. https://doi.org/10.1021/acs.orglett.0c03511
Williams, D. R., Gladen, P. T., Pinchman, J. R. Total Synthesis of Neodolastane Diterpenes Trichoaurantianolides C and D. Journal of Organic Chemistry, 2015, 80, 5474–5493. https://doi.org/10.1021/acs.joc.5b00355
*Research by Lake Forest College undergraduate co-workers
Presentations
Gladen, P. T., Abbasov, M. E. and Romo, D. Towards a Bioactivity Guided Synthesis of the Oxazolomycins. (May 2015) Poster session at TexSyn II Conference, University of Texas at San Antonio.
Gladen, P. T., Williams, D. R., Pinchman, J. R. Studies Toward the Total Synthesis of the Trichoaurantianolides. (September 2013) Poster session at ACS National Meeting Indianapolis.