Academics

Human Neurons in Rat Neural Circuits

March 07, 2023
Olivia Godek

 The concern regarding whether animal-based research models can produce results applicable to humans has long been well-integrated within the field of neuroscience. A recent study has shown that human cortical organoids (hCO) developed from human induced pluripotent cells (hiPS) and transplanted into the primary somatosensory cortex (S1) of rats in early development can undergo maturation and integration into the rat’s existing neural circuits (Revah et al., 2022). The implications of such findings are extensive, although the primary goal of the researchers was to utilize the model as a means of studying human neurodegenerative and neuropsychiatric disorders. 

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