Associate Professor of Biology
Integrative developmental biology: developmental biology, physiology and evolution.
Our laboratory studies the molecular-genetic and physiological regulation of body and organ size, and how this regulation evolves. We integrate molecular biology, physiology and evolutionary biology to generate a synthetic understanding of why animals are the size and shape that they are. Our research uses the fruit fly, Drosophila melanogaster, as a model organism for animal development.
See my research webpage for complete details.
Postdoctoral Fellow, Ecology and Evolutionary Biology, Princeton University
PhD Zoology, Clare College, University of Cambridge
BA Zoology, St. Peter’s College, University of Oxford
08.2013 –: Associate Professor, Department of Biology, Lake Forest College
07.2012 – 08.2013: Associate Professor, Department of Zoology, Michigan State University
01.2006 – 06.2012: Assistant Professor, Department of Zoology, Michigan State University:
Selected Courses Taught
Biology 120L: Organismal Biology
Biology 131: Biological Inquiry: The biology of Dogs
Biology 389: Evolution
For complete list see here .
Oliveira, M.M., Shingleton, A.W., Mirth, C.K. 2014. Coordination of wing and whole body development at developmental milestones ensures robustness against environmental and physiological perturbations. PLoS Genetics. In Press.
Mirth, C.K., Tang, H., Makohon-Moore, S., Salhadar, S., Gokhale, R.H., Warner, R.D., Koyama, T., Riddiford, L.M., Shingleton, A.W., 2014. Juvenile hormone regulates body size and perturbs insulin-signaling in Drosophila. Proceedings of the National Academy of Science, doi: 10.1073/pnas.1313058111
Callier, V., Shingleton, A.W., Brent, C.S., Ghosh, S.M., Kim, J., Harrison, J.F., 2013. The role of reduced oxygen in the developmental physiology of growth and metamorphosis initiation in Drosophila melanogaster. The Journal of Experimental Biology, 216, 4334-4340
Ghosh, S.M., Testa, N.D., Shingleton, A.W. 2013. Tempertature Size Rule is mediated by thermal plasticity of critical size in Drosophila melanogaster. Proceedings of the Royal Society, London. Series B. 280, no 1760.
Testa, N.D., Ghosh, S.M., Shingleton, A.W. 2013. Sex-specific weight loss mediates sexual size dimorphism in Drosophila melanogaster. PLoS One, 8(3): e58936.
Shingleton, A.W., Tang, H.Y. 2012. Plastic flies: The regulation and evolution of trait variability in Drosophila. Fly, 6, 1-3
Tang, H., Smith-Caldas, M.S.R., Driscoll, M.V., Salhadar, S. &Shingleton, A.W. 2011. FOXO regulates organ-specific phenotypic plasticity in Drosophila. PLoS Genetics, 7, e1002373
Parker, N.F. & Shingleton, A.W. 2011. The coordination of growth among Drosophila organs in response to localized growth perturbation. Developmental Biology, 357, 318-325
Shingleton, A.W., Estep, C.M., Driscoll, M.V., Dworkin, I. 2009.Many ways to be small: Different environmental regulators of size generate different scaling relationships in Drosophila melanogaster. Proceedings of the Royal Society, London. Series B. 276, 2625-2633
Stieper, B.C., Kupershtok, M., Driscoll, M.V. & Shingleton, A.W. 2008. Imaginal disc growth regulates the timing of metamorphosis in Drosophila melanogaster. Developmental Biology. 321, 18-26
Shingleton, A.W., Mirth, C.K. & Bates, P.W. 2008. Developmental model of static allometry in holometabolous insects. Proceedings of the Royal Society, London. Series B. 275, 1875-1885
Shingleton, A.W., Das, J., Vinicius, L. & Stern, D.L. 2005. The temporal requirements for insulin signaling during development in Drosophila, PLoS Biology, 3 (9)
Shingleton, A.W., Frankino, W.A. 2013. New perspectives on the evolution of exaggerated traits. BioEssays. 35, 100-107
Kültz, D., Clayton, D.F., Robinson, G.E., Albertson, C., Carey, H.V., Cummings, M.E., Dewar, K., Edwards, S.V., Hofmann, H.A., Gross, L.J., Kingsolver, J.G., Meaney, M.J., Schlinger, B.A., Shingleton, A.W., Sokolowski, M.B., Somero, G.N., Stanzione, D.C., Todgham, A.E. 2013. New frontiers for organismal biology. BioScience. 63, 464-471.
Mirth, C.K., Shingleton, A.W. 2012. Intergrating body and organ size in Drosophila: recent advances and outstanding problems. Frontiers in Experimental Endocrinology, 3:49
Shingleton, A.W. 2010. Allometry. Nature Education Knowledge. 1(9):2
Shingleton, A.W., Frankino, W.A., Flatt, T. Nijhout, H.F. & Emlen, D.J. 2007. Size and Shape: The regulation of static allometry in insects, BioEssays, 29 (6), 536-548
Shingleton, A.W. 2005, Body-Size Regulation: Combining Genetics and Physiology, Current Biology, 15 (20), R825-R827
Shingleton, A.W. 2011. The regulation and evolution of growth and body size. in “Mechanisms of Life History Evolution” (T. Flatt & A. Heyland, Eds), OUP
Frankino, W.A., Emlen, D.J. & Shingleton, A.W. 2009.Experimental approaches to studying the evolution of morphological allometries: The shape of things to come. in “Experimental Evolution” (T. Garland & M.R. Rose, Eds), University of California Press, Berkley.
2013 – 2016: NSF (IOS-1256565): Is hypoxia a critical cue for molting in Drosophila? ($326,000). PI: Shingleton
2009 – 2014: NSF (IOS-0919855): CAREER: Size Matters – The control of allometry in Drosophila. ($591,517). PI: Shingleton
2009 – 2013: NSF (IOS-0845847): Tipping the Scales - A selection approach to the developmental regulation of morphological scaling ($218,626). PI: Shingleton; Co-PI: I. Dworkin