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Psychology

David Rademacher

Posing in front of the Colosseum in Rome, Italy (May, 2013).Posing in front of the Colosseum in Rome, Italy (May, 2013).

Visiting Assistant Professor of Psychology

Accomplishments

  • Published 37 peer-reviewed research articles
  • 1,623 citations, h-index = 18, i10 index = 25
  • Taught 32 courses over 14 years
  • Greater than 45 presentations of original research at scientific conferences
  • 15 invited scientific talks and presentations
  • Total funding from grant agencies in excess of $1 million
  • Supervised 15 graduate students, technicians, and medical students
  • Member of a key regulatory committee at a Big Ten university
  • Ad hoc reviewer for 10 scientific journals
  • Maintained an independent laboratory for 7 years
  • Recipient of numerous awards for academic and scientific excellence
  • Served as a grant reviewer at a Big Ten university
  • 16 years of experience working in laboratory setting

Education

Postdoctoral Fellow, Rosalind Franklin University
Postdoctoral Fellow, Medical College of Wisconsin
PhD, University of Wisconsin- Milwaukee
MS, University of Wisconsin-Milwaukee
BA, Hamline University

Research Interests

Structural and functional plasticity in neuronal circuits, drug addiction, learning and memory, Parkinson’s disease, epigenetics, neurotoxicology, endocannabinoid signaling, and animal models (e.g., addiction, anxiety, depression)

Lab Skills

in vivo microdialysis, liquid chromatography with electrochemical detection, drug self-administration, conditioned place preference, elevated plus maze, tests of social behavior, Western blots, stereotaxic surgery, tissue sectioning (cryostat, sliding microtome, vibratome), liquid chromatography-mass spectrometry, enzyme activity assays, receptor binding assays, chronic stress paradigms, enzyme-linked immunosorbent assay, model of anhedonia, chronic cannulation with repeated drug infusions, cell type isolation techniques, cell culture, immunocytochemistry, immunohistochemistry, immunofluorescence, stereology, quantitative electron microscopy, focused ion beam scanning electron microscopy, laser scanning confocal microscopy, calcium imaging, and tract tracing.

Courses Taught

Introduction to Psychology, Introduction to Psychology Lab, Experimental Psychology, Research Methods and Statistics I and II, Research Methods and Statistics I and II Lab, History of Psychology, Sensation and Perception, Behavioral Research Statistics, Introduction to Behavioral Neuroscience, Neuroscience and Behavior, Neuroscience and Behavior Lab

Articles

Collier TJ, O’Malley J, Rademacher DJ, Stancati JA, Sisson KA, Sortwell CE, Paumier KL, Gebremedin KG, Steece-Collier K. Interrogating the aged striatum: robust survival of grafted dopamine neurons produces inferior behavioral recovery and evidence of impaired integration. Neurobiology of Disease. 77:191-203. doi: 10.1016/j.nbd.2015.03.005, May 2015, PMID: 25771169.

Rademacher DJ, Mendoza-Elias N, Meredith, GE. Effects of context-drug learning on synaptic connectivity in the basolateral nucleus of the amygdala in rats. European Journal of Neuroscience. 41(2): 205-215. doi: 10.1111/ejn.12781, Jan 2015, PMID: 25359418.

Figge DA, Rahman I, Dougherty PJ, Rademacher DJ. Retrieval of contextual memories increases activity-regulated cytoskeleton-associated protein in the amygdala and hippocampus. Brain Structure and Function. 218(5):1177-1196. doi: 10.1007/s00429-012-0453-y, Sept 2013, PMID: 22945419.

Zhang Y, Meredith GE, Mendoza-Elias N, Rademacher DJ, Tseng KY, Steece-Collier K.  Aberrant restoration of spines and their synapses in L-dopa-induced dyskinesia: involvement of corticostriatal but not thalamostriatal synapses. Journal of Neuroscience, 33(28):11655-11667, doi: 10.1523/JNEUROSCI.0288-13.2013, Jul 2013, PMID:23843533.

Levine ND, Rademacher DJ, Collier TJ, O’Malley JA, Kells AP, San Sebastian W, Bankiewicz KS, Steece-Collier K. Advances in thin tissue Golgi-Cox impregnation: rapid, reliable methods for multi-assay analyses in rodent and non-human primate brain. Journal of Neuroscience Methods, 213(2):214-227, doi:10.1016/j.jneumeth.2012.12.001, Mar 2013, PMID:23313849. 

Steece-Collier K, Rademacher DJ, Soderstrom K. Anatomy of graft-induced dyskinesias: circuit remodeling in the parkinsonian striatum. Basal Ganglia, 2(1):15-30, Mar 2012, PMID:22712056.

Hetzel A, Meredith GE, Rademacher DJ, Rosenkranz JA. Effect of amphetamine place conditioning on excitatory synaptic events in the basolateral amygdala ex vivo. Neuroscience, 206:7-16, doi:10.1016/j.neuroscience.2012.01.015, Mar 2012, PMID:22280974.

Meredith GE, Rademacher DJ. MPTP mouse models of Parkinson’s disease. Journal of Parkinson’s Disease, 1(1):19-33, doi:10.3233/JPD-2011-11023, June 2011, PMID:23275799.

Rademacher DJ, Rosenkranz JA, Morshedi MM, Sullivan EM, Meredith GE. Amphetamine-associated contextual learning is accompanied by structural and functional plasticity in the basolateral amygdala. Journal of Neuroscience, 30(13):4676-4686, doi: 10.1523/JNEUROSCI.6165-09.2010, Mar 2010, PMID:20357118.

Rademacher DJ, Sullivan EM, Figge DA. The effects of infusions of CART 55-102 into the basolateral amygdala on amphetamine-induced conditioned place preference in rats. Psychopharmacology, 208(3):499-509, doi:10.1007/s00213-009-1748-4, Feb 2010, PMID:20013112.

Morshedi MM, Rademacher DJ, Meredith GE. Increased synapses in the medial prefrontal cortex are associated with repeated amphetamine administration. Synapse, 63(2):126-135, doi:10.1002/syn.20591, Feb 2009, PMID:19016489.

Rademacher DJ, Meier SE, Shi L, Ho WS, Jarrahian A, Hillard CJ. Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice. Neuropharmacology, 54(1):108-116, Jan 2008, PMID:17675104.

Rademacher DJ, Napier TC, Meredith GE. Context modulates the expression of amphetamine motor sensitization, cellular activation, and synaptophysin immunoreactivity. European Journal of Neuroscience, 26(9):2661-2668, Nov 2007, PMID:17970739.

Rademacher DJ, Hillard CJ. Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(3):633-641, Apr 2007, PMID:17258369.

Rademacher DJ, Kovacs B, Shen F, Napier TC, Meredith GE. The neural substrates of amphetamine conditioned place preference: implications for the formation of conditioned stimulus-reward associations. European Journal of Neuroscience, 24(7): 2089-2097, Oct  2006, PMID:17067306.

Rademacher DJ, Patel S, Ho WS, Savoie AM, Rusch NJ, Gauthier KM, Hillard CJ. U-46619 but not serotonin increases endocannabinoid content in the middle cerebral artery: evidence for functional relevance. American Journal of Physiology: Heart and Circulatory Physiology, 288(6): H2694-H2701, June 2005, PMID: 15695564.

Hill MN, Patel S, Carrier EJ, Rademacher DJ, Ormerod BK, Hillard CJ, Gorzalka BB. Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress. Neuropsychopharmacology, 30(3):508-515, Mar 2005, PMID:15525997.

Patel S, Roelke CT, Rademacher DJ, Hillard CJ. Inhibition of restraint stress-induced  neural and behavioural activation by endogenous cannabinoid signalling. European Journal of Neuroscience, 21(4):1057-1069, Feb 2005, PMID:15787710.

Patel S, Carrier EJ, Ho WS, Rademacher DJ, Cunningham S, Reddy DS, Falck JR, Cravatt BF, Hillard CJ. The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. Journal of Lipid Research, 46(2):342-349, Feb 2005, PMID:15576840.

Rademacher DJ, Weber DN, Hillard CJ. Waterborne lead exposure affects brainendocannabinoid content in male but not female fathead minnows (Pimephales promelas). NeuroToxicology, 26(1):9-15, Jan 2005, PMID:15527869.

Muthian S, Rademacher DJ, Roelke CT, Gross GJ, Hillard CJ. Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia. Neuroscience, 129(3):743-750, Dec 2004, PMID:15541895.

Patel S, Roelke CT, Rademacher DJ, Cullinan WE, Hillard CJ. Endocannabinoidsignaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. Endocrinology, 145(12):5431-5438, Dec 2004, PMID:15331569.

Rademacher DJ, Kearn CS, Carrier EJ, Patel S, Delgado MA, Barkmeier A, Klick DE, Breese NM, Pfister SL, Nithipatikom K, Campbell WB, Hillard CJ. Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line.  Journal of Neuroimmunology, 149(1-2):130-141, Apr 2004, PMID:15020073.

Seagard JL, Dean C, Patel S, Rademacher DJ, Hopp FA, Schmeling WT, Hillard CJ. Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition. American Journal of Physiology:  Heart and Circulatory Physiology, 286(3):H992-H1000, Mar 2004, PMID:14615281. 

Patel S, Rademacher DJ, Hillard CJ. Differential regulation of the endocannabinoidsanandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. The Journal of Pharmacology and Experimental Therapeutics, 306(3):880-888, Sep 2003, PMID:12808005.

Patel S, Wohlfeil ER, Rademacher DJ, Carrier EJ, Perry LJ, Kundu A, Falck JR, Nithipatikom K, Campbell WB, Hillard CJ. The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. British Journal of Pharmacology, 139(5):1005-1013, Jul 2003, PMID:12839875.

Rademacher DJ, Patel S, Hopp FA, Dean C, Hillard CJ, Seagard JL. Microinjection of acannabinoid receptor antagonist into the NTS increases baroreflex duration in dogs. American Journal of Physiology. Heart and Circulatory Physiology, 284(5):H1570-H1576, May 2003, PMID:12521935.

Rademacher DJ, Steinpreis RE, Weber DN. Effects of dietary lead and/ordimercaptosuccinic acid exposure on regional serotonin and serotonin metabolite content in rainbow trout (Oncorhynchus mykiss). Neuroscience Letters, 339(2):156-160, Mar 2003, PMID:12614918.

Rademacher DJ, Schuyler AL, Kruschel CK, Steinpreis RE. Effects of cocaine andputative atypical antipsychotics on rat social behavior: an ethopharmacological study. Pharmacology, Biochemistry, and Behavior, 73(4):769-778, Nov 2002, PMID:12213521.

Rademacher DJ, Steinpreis RE. Effects of the selective mu(1)-opioid receptor antagonist,naloxonazine, on cocaine-induced conditioned place preference and locomotor behavior in rats. Neuroscience Letters, 332(3):159-162, Nov 2002, PMID:12399005.

Rademacher DJ, Anderson AP, Steinpreis RE. Acute effects of amperozide andparoxetine on social cohesion in male conspecifics. Brain Research Bulletin, 58(2), 187-191, Jun 2002, PMID:12127016.

Rademacher DJ, Steinpreis RE, Weber DN. Short-term exposure to dietary Pb and/orDMSA affects dopamine and dopamine metabolite levels in the medulla, optic tectum, and cerebellum of rainbow trout (Oncorhynchus mykiss). Pharmacology, Biochemistry, and Behavior, 70(2-3):199-207, Oct-Nov 2001, PMID:1171189.

Rademacher DJ, Anders KA, Thompson KJ, Steinpreis RE. The failure of some rats toacquire intravenous cocaine self-administration is attributable to conditioned place aversion. Behavioural Brain Research, 117(1-2):13-19, Dec 2000, PMID:11099753.

Rademacher DJ, Anders KA, Riley MG, Nesbitt JT, Steinpreis RE. Determination of theplace conditioning and locomotor effects of amperozide in rats: a comparison with cocaine.Experimental and Clinical Psychopharmacology, 8(3): 434-443, Aug 2000, PMID:10975635.

Zhou T, Rademacher DJ, Steinpreis RE, Weis JS. Neurotransmitter levels in twopopulations of larval Fundulus heteroclitus after methylmercury exposure. Comparative Biochemistry and Physiology. C: Pharmacology, Toxicology, and Endocrinology, 124(3): 287-294, Nov 1999, PMID:10661721.

Panos JJ, Rademacher DJ, Renner SL, Steinpreis RE. The rewarding properties of NMDAand MK-801 (dizocilpine) as indexed by the conditioned place preference paradigm. Pharmacology, Biochemistry, and Behavior, 64(3):591-595, Nov 1999, PMID:10548276.

Rademacher DJ, Kuppinger HE, Thompson KJ, Harrington A, Kaczmarek HJ, Kopish AJ, Steinpreis RE. The effects of amperozide on cocaine-induced social withdrawal in rats. Behavioural Brain Research, 99(1):75-80, Feb 1999, PMID:10512574.

Research Grants and Awards

Hamline University, 1992-1994, Presidential Fellowship Scholarship

Sigma Xi, 1997, Grants-in-Aid of Research Award

National Research Service Award, National Institute on Drug Abuse, 1999-2001, CNS Mediation of Cocaine-Induced Substrate Interactions

American Psychological Association Science Directorate, 2001, American Psychological Association Dissertation Research Award

National Research Service Award, National Institute on Drug Abuse, 2003-2005, Characterization of the Anandamide Uptake Transporter

Research Project Grant, National Institute on Drug Abuse, 2007-2009, CART Peptide Modulation of Stimulant Reward

Small Research Project Grant, National Institute on Drug Abuse, 2009-2011, The Role of Activity-Regulated Cytoskeletal-Associated Protein in Amphetamine Place Conditioning