D-Lab: Publications & Talks

Undergraduate Authors (*); Co-first authors:#

Manuscripts in preparation

Senagolage, M*#, Perez, J*#, Ayala, A*, Vahedi, M*, Price, J*, Fiske, M*, Khan, R*, Tembo, M*, and DebBurman, SK. Complex regulation of alpha-synuclein pathotoxic properties in yeasts by endocytosis genes.  #: co-first authors. In prep.

Konnikova, A*, Choi, R*, Sanchez, D*, Ahlstrand, K*, Sullivan, P*, Perez, J*, and DebBurman, SK. Autophagic regulation of alpha-synuclein membrane association, aggregation and toxicity in  budding yeast. 

DebBurman, SK, Rizvydeen*, S, Konnikova, A*, Fiske, M*, Davis, S*, Pore, S*, Zorniak, M*, Brandis, K*, and Smith, P. EUKARYON: An undergraduate peer-reviewed life sciences journal that strengthens an inquiry-based biology curriculum and supports and community of students as scholars. 

DebBurman, SK. An advanced cell biology course designed for undergraduates to propose, conduct, and publish original biomedical research.

Current Projects

Solvang, K*, Fiske, M*, DebBurman, SK. Alpha-synuclein nitrosylation regulates aggregation and cellular toxicity in budding yeast.

Kukulka, N*, DebBurman, SK. Combination mutant analysis of familial Parkinson’s disease  alpha-synuclein mutants in two yeast models: Not all mutants are equal.

Campbell, K*, Lipkin, G*, Solvang, K*, DebBurman, SK. Amino acid determinants of alpha-synuclein membrane association, aggregation and toxicity.

Roman, A*, Lipkin, G*, Hamid, K*, Campbell, K*, DebBurman, SK. Evaluation of alpha-synuclein sumoylation in yeasts.

Tembo, M*, Munoz M*, DebBurman, SK. Evaluation of H50Q and G51D familial alpha-synuclein familial mutants in yeast.

Bello Rojas S*, Hamid K*, Graham, L*, Gudmundson, A*, McCracken, A*, Schrag, P*, Kukulka, N*, DebBurman, SK. Evaluation of alpha-synuclein splice variants in yeast.

Alvarado, C*, Chiren, S*, James, J*, Roman, A*, Munoz, M*, Campbell, K*, and DebBurman, SK. Evaluation of alpha-synuclein C-terminal truncations in yeast.

Hamid, K*, Campbell, K*, and DebBurman, SK. Evaluation of alpha-synuclein N-terminal truncations in yeast.

Published Articles

2011 Fiske, M*#, Valtierra, S*,# Solvang, K*, Zorniak, M*, White, M.*, Herrera, S*, Brezinsky, R*, Konnikova, A* and DebBurman, SK. Contribution of serine phosphorylation and alanine-76 to alpha-synuclein membrane association and aggregation in yeast models.  Parkinson’s Disease Volume 2011, 12 pages, Article ID 392180; doi:10.4061/2011/392180
#: co-first authors.

2011 Fiske, M*#, White M*#,  Valtierra, S*, Herrera, S*, Solvang, K*, Konnikova, A* and DebBurman, SK. E46K Alpha-Synuclein Familial Mutant Binds Membranes, Aggregates, and Induces Strain-Selective Toxicity in Yeast Models. ISRN Neurology, vol. 2011, Article ID 521847, 14 pages, 2011.
doi:10.5402/2011/521847
#: co-first authors
.


2006 Sharma, N*#, Brandis, K*#, Herrera, SK*, Johnson, BE*, Vaidya, T*, Srestha R*, and DebBurman, SK. (2006) Alpha-SYNUCLEIN BUDDING YEAST MODEL: Toxicity Enhanced By Impaired Proteasome and Oxidative Stress. Journal of Molecular Neuroscience 28, 171-178. #: co-first authors

2006 Brandis, K*, Holmes, I*, England, S*, Sharma, N*, Kukreja, L*, and DebBurman, SK. Alpha-SYNUCLEIN FISSION YEAST MODEL: Concentration-Dependent Aggregation Without Membrane Localization or Toxicity. Journal of Molecular Neuroscience 28, 179-192.

2002 DebBurman, S.K. Learning How Scientists Work: Experiential research projects to promote cell biology learning and scientific process skills. Cell Biology Education 1, 154-172.

1999 Caughey, B, Chabry, J, Hermann, L, Demaimey, R, Raymond, G, Raymond, L, DebBurman, SK, Lindquist, SL, & B Chesebro. Formation of protease-resistant prion protein: Stimulation and inhibition, in Alzheimer’s Disease and Related Disorders (Edited by K Iqbal, DF Schwab, B Winblad, and HM Wisniewski), John Wiley & Sons, 581-587.

1998 Lindquist, SL, DebBurman, SK, Glover, JR, Kowal, AK, Liu, J, & TC Serio.  Amyloid fibers of Sup35 support a prion-like mechanism of inheritance in yeast. Biochemical Society Transactions 26, 486-90.

1997 DebBurman, SK, Raymond, GJ, Caughey, B, & SL Lindquist (1997) Chaperone-supervised conversion of prion protein to its protease-resistant form. Proceedings of the National Academy of Sciences USA. 97, 13938-13943.

* Highlighted as Nature News & Views: by Welch, WJ, and P Gambetti. Nature 392, 23-24 (1998)
* Highlighted in New Scientist This Week by Philip Cohen. New Scientist 2112, December 13, 1997, p8.
* Highlighted in Folding & Design 3, 1998, R41 (as a new paper alert).

1996 Hosey, MM, DebBurman, SK, Pals-Rylaarsdam, R, & JL Benovic.  The Role of G protein-coupled receptor kinases in the regulation of muscarinic cholinergic receptors, in “Cholinergic mechanisms: From Molecular Biology to Clinical Significance” (Proceedings of the Ninth International Symposium on Cholinergic Mechanisms), Progress in Brain Research (Editors: K. Loffelholz and K. Klein), Elvesier, 236-253.

1996 DebBurman, SK, Ptasienski, J, Benovic, JL, & MM Hosey.  G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that is conditionally activated by G protein beta-gamma subunits.  Journal of Biological Chemistry  271, 22552-22561.

1995 Hosey, MM, Benovic, JL, DebBurman, SK, & RM Richardson.  Multiple mechanisms involving protein phosphorylation are linked to desensitization of muscarinic receptors, Proceedings of the Sixth International Symposium on Subtypes of Muscarinic Receptors) Life Sciences 11/12, 951-955.

1995 DebBurman, SK, & MM Hosey. Role of Protein Phosphorylation in the Desensitization of Muscarinic Cholinergic Receptors, in Molecular Mechanisms of Muscarinic Acetylcholine Receptor Function (Editor: J. Wess), R.G. Landes Company, Biomedical Publishers, Austin, USA, 209-226.

1995 DebBurman, SK, Ptasienski, J, Boetticher, E., Lomasney, JW, Benovic, JL, & MM Hosey.  Lipid-mediated regulation of G protein-coupled receptor kinases GRK2 & GRK3. Journal of Biological Chemistry 270, 5742-5747.

1995 DebBurman, SK, Kunapuli, P, Benovic, JL, & MM Hosey. Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases. Molecular Pharmacology 47, 224-233.

Student Publications in Undergraduate Journals

Note: the papers below were published in national peer-reviewed undergraduate journals

2009 Kukreja, L., and DebBurman, SK. Oxidants Induce alpha-Synuclein-Independent Toxicity in a Fission Yeast Model for Parkinson’s Disease. Journal of Young Investigators. Volume 19, Issue 17 on 03 November.  (http://www.jyi.org/research/re.php?id=3529)

2008 Kukreja, L* (Faculty Advisor: DebBurman, SK.) Evaluating alpha-synuclein’s interaction with cellular phospholipids and potential toxicity in yeast models for Parkinson’s disease. AJUR: The Journal for undergraduate research in the pure and applied sciences, Vol 7, 9-24.

2007 Zorniak, M* & Brandis, K* (Faculty Advisor: DebBurman, SK.) Can Oxidative Stress and Mitochondrial Dysfunction Enhance alpha-synuclein Toxicity in a Yeast Model of Parkinson’s Disease?
Journal of Young Investigators Vol 17, issue 6.
WebID: http://www.jyi.org/articletools/print.php?id=1350

2006 Paul, AG* (Faculty Advisor: DebBurman, SK.)  Evaluation of STP2-dependent alpha-synuclein toxicity in a budding yeast model: Is GAPDH involved? Impulse: Impulse: An Undergraduate Journal in Neuroscience.


Invited Talks

2014 “Undergraduates drive insights into Parkinson’s Disease using yeast models”, University of Chicago

2014 “The Juggling Act of a Small College Professor: Why be one and how to prepare for it”, University of Chicago

2013 “Undergraduates drive insights into Parkinson’s Disease using yeast models”, Neuroscience Graduate Program, University of Wisconsin - Madison

2013 “The Juggling Act of a Small College Professor: Why be one and how to prepare for it”, Neuroscience Graduate Program, University of Wisconsin - Madison

2013 “Preparing for a Career as a Liberal Arts College Professor: The Nuts and Bolts”, Molecular & Environmental Toxicology Program, University of Wisconsin - Madison

2012 “Yeasts and Undergraduates help Understand Parkinson’s Disease Pathology”, University of Buffalo, Buffalo, NY

2012 “Preparing for a Career as a College Professor: Juggling Three Hats” University of Buffalo, Buffalo, NY

2012 “Careers: Teaching & research at a small liberal arts college” Northwestern University, IL

2011 “Value of an undergraduate liberal arts education at a small college in the United States”, at several high schools in India, including Delhi Public School (Gurgaon), Heritage School (Gurgaon), American Embassy School (New Delhi), United World Colleges Mahindra (Pune), KIIT University (Bhubaneswar)

2011 “New Insights into Parkinson’s Disease from Yeast Models”, Rosalind Franklin University of Medicine and Science, North Chicago, IL

2011 “Preparing for a Career as a College Professor: Teacher, Scholar, & Citizen”, Rosalind Franklin University of Medicine and Science, North Chicago, IL

2011 “How Undergraduates use Yeasts to Drive New Insights into Parkinson’s disease”, Roosevelt University, Chicago, IL

2011 “Modeling a Protein Misfolding Disease in Yeasts”. Dominican University, River Forest, IL

2009 Tips to Start and Sustain a Student-Centered Research at a Liberal Arts College, American Society of Cell Biology Meeting, San Francisco, CA

2008 The Job Search & Interview Process, Panelist, Northwestern University Directions Professional Development Conference, Evanston, IL

2008 The Job Search & Interview Process, Panelist, Preparing Future Faculty Workshop, Oakton Community College, IL

2008 Tips to Start and Sustain a Student-Centered Research at a Liberal Arts College, American Society of Cell Biology Meeting, San Francisco, CA

2008 Insight into Parkinson’s Disease From Yeast Models, Rush Medical College/Rush University

2008 The 21st Century College Professor: Teacher, Scholar, & Citizen, Rush Medical College/Rush University

2007 A Faculty Career At a Liberal Arts College Careers in Pharmacology Workshop, Great Lakes Chapter-American Society of Pharmacology and Experimental Therapeutics meeting

2005  A Toxic Shape, A Tragic Consequence: Yeasts & Undergraduates Help Understand Parkinson’s Disease, Skidmore College

2005 “Modeling Parkinson Disease: Two Yeasts, Distinct Insights” Loyola Stritch School of Medicine, IL

2005 “Mentoring Preparing Future Faculty Fellows in Biology at Lake Forest College”, Northwestern Feinberg School of Medicine

2005 “Careers: Teaching & research in a small liberal arts college” Loyola Stritch School of Medicine, IL
 
2005 “Integrating Teaching, Scholarship, & Service to Strengthen Undergraduate Student Scholarship”, Pedagogies of Engagement, An American Association of Colleges & Universities (AACU) Meeting, Bethesda MD

2004 “Protein Misfolding & Neurodegeneration: Insights from Chaperones and Yeast”, Purdue University, West Lafayette, IN

2004 “Pedagogical Scholarship: Translating Philosophy Into Practice” Purdue University, West Lafayette, IN

2004 “Insights into Prion Disease and Parkinson Disease from Chaperones & Yeasts”, University of Illinois at Chicago, IL

2004 “Probing Yeasts to Gain Insight Into Neurodegeneration Linked to Parkinson Disease”, Rosalind Franklin University/Chicago Medical School, IL

2004 “Protein Misfolding & Neurodegeneration: Insights from Chaperones and Yeast”, Purdue University, Calumet City, IN

2004 “A Career as a College Professor: The Specifics of How To Get To Where You Want To Be”, American Society of Pharmaceutical & Experimental Therapeutics (ASPET) Committee on Minorities Affairs, Annual Meeting of Experimental Biology, Washington, DC

2004 “Careers: Teaching & research in a small liberal arts college” Northwestern University, IL

2002 “The Small Liberal Arts College: Is this for You?”
(Beyond Books Series panel discussion on Alternate Careers in Academia, Preparing Future Faculty Program), Northwestern University, IL
 
2000 “Combating Neurodegeneration”, Biology Department, Lake Forest College, IL

2000 “Combating Diseased Protein Shapes With Molecular Chaperones”, Biology Department, Grinnell College, IA

2000 “Deadly Protein Shapes In Human Disease”, Joint Sciences Department, Claremont Colleges, CA

1999 “Combating Diseased Protein Shapes With Molecular Chaperones”, Department of Biology, Macalester College, MN

1999 “Careers: Teaching & Research In A Small Liberal Arts College” (A Bio-Opportunities Workshop) Northwestern University Medical School, IL

1999 “Diseased Protein Shapes: Combating Them With Molecular Chaperones”, Department of Biology, Western Michigan University, MI

1999 “Combating Neurodegenerative Diseases With Molecular Chaperones”, Faculty Seminar Series, Kalamazoo College, MI

1999 “Combating Neurodegenerative Diseases With Molecular Chaperones”, Department of Biology, Hope College, MI

1998 “Prions: Novel Agents Of Genetic Inheritance And Infectious Disease”, Pharmacia-Upjohn Company, Kalamazoo, MI

1998 “Molecular Chaperones & Mammalian Prion Formation”
BIOMEDICINE Meeting-American Federation of Medical Research, Washington DC

1998 “Prions: Agents Of Mad Cow Disease”, Department of Biology, Kalamazoo College, MI

1998 “Do Prions Cause Mad Cow Disease?”, Department of Biology, Alma College, MI

1997 “An Expanding World Of Prions”, NIH Rocky Mountain Laboratories, Hamilton, MT

1997 “Molecular Chaperones & Misfolded Proteins: Implications In Neurodegenerative Disease”, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, MD

1997 “Protein Conformation Switches: In Health & Disease”, Department of Biology, Wittenberg University, Springfield, OH

1997 “Mad Cow Disease: Can We Cure It?”, Department of Biology, Lake Forest College, IL


Other Talks

2002 “Experiential research projects promote learning an inquiry-based undergraduate science curriculum”, Undergraduate Research Network, National Council of Undergraduate Research, Whitewater, WI

1997 “Molecular chaperones modulate prion conformation switch” Midwest Stress Response & Chaperones Conference, Chicago, IL

1996 “Phosphorylation and regulation of G protein-coupled receptors” Department of Molecular Pharmacology & Biological Chemistry, Northwestern University Medical School, Chicago, IL

1995 “Lipid mediated regulation of G protein-coupled receptor kinases GRK2 and GRK3”, Graduate Research Symposium, Society for Neuroscience-Annual meeting of the Chicago Chapter, Chicago, IL

1995 “Molecular basis of homologous desensitization of G protein-coupled receptors”, Howard Hughes Medical Institute, University of Chicago, IL

1995 “G protein-coupled receptor regulation by protein phosphorylation”, Department of Biochemistry, Molecular Biology & Biochemistry, Northwestern University, IL