Academics

Articles Undergraduate Authors (asterisked)
2006 Sharma, N*, Brandis, K*, Herrera, SK*, Johnson, BE*, Vaidya, T*, Srestha R*, and DebBurman, SK. (2006) alpha- SYNUCLEIN BUDDING YEAST MODEL: Toxicity Enhanced By Impaired Proteasome and Oxidative Stress. Journal of Molecular Neuroscience 28, 171-178.

2006 Brandis, K*, Holmes, I*, England, S*, Sharma, N*, Kukreja, L*, and DebBurman, SK. alpha-SYNUCLEIN FISSION YEAST MODEL: Concentration-Dependent Aggregation Without Membrane Localization or Toxicity. Journal of Molecular Neuroscience 28, 179-192.

Note: the paper below was published in a national undergraduate journal peer-reviewed by undergraduates

2006 Paul, AG* (Faculty Advisor: DebBurman, SK.)  Evaluation of STP2-dependent alpha-synuclein toxicity in a budding yeast model: Is GAPDH involved? Impulse: Impulse: An Undergraduate Journal in Neuroscience.

2002 DebBurman, S.K. Learning How Scientists Work: Experiential research projects to promote cell biology learning and scientific process skills. Cell Biology Education 1, 154-172.

1999 Caughey, B, Chabry, J, Hermann, L, Demaimey, R, Raymond, G, Raymond, L, DebBurman, SK, Lindquist, SL, & B Chesebro. Formation of protease-resistant prion protein: Stimulation and inhibition, in Alzheimer's Disease and Related Disorders (Edited by K Iqbal, DF Schwab, B Winblad, and HM Wisniewski), John Wiley & Sons, 581-587.

1998 Lindquist, SL, DebBurman, SK, Glover, JR, Kowal, AK, Liu, J, & TC Serio.  Amyloid fibers of Sup35 support a prion-like mechanism of inheritance in yeast. Biochemical Society Transactions 26, 486-90.

1997 DebBurman, SK, Raymond, GJ, Caughey, B, & SL Lindquist (1997) Chaperone-supervised conversion of prion protein to its protease-resistant form. Proceedings of the National Academy of Sciences USA. 97, 13938-13943.

• Highlighted as Nature News & Views: by Welch, WJ, and P Gambetti.  Nature 392, 23-24 (1998)
• Highlighted in New Scientist This Week by Philip Cohen. New Scientist 2112, December 13, 1997, p8. 
• Highlighted in Folding & Design 3, 1998, R41 (as a new paper alert).

1996 Hosey, MM, DebBurman, SK, Pals-Rylaarsdam, R, & JL Benovic.  The Role of G protein-coupled receptor kinases in the regulation of muscarinic cholinergic receptors, in "Cholinergic mechanisms: From Molecular Biology to Clinical Significance" (Proceedings of the Ninth International Symposium on Cholinergic Mechanisms), Progress in Brain Research (Editors: K. Loffelholz and K. Klein), Elvesier, 236-253.

1996 DebBurman, SK, Ptasienski, J, Benovic, JL, & MM Hosey.  G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that is conditionally activated by G protein beta-gamma subunits.  Journal of Biological Chemistry  271, 22552-22561.

1995 Hosey, MM, Benovic, JL, DebBurman, SK, & RM Richardson.  Multiple mechanisms involving protein phosphorylation are linked to desensitization of muscarinic receptors, Proceedings of the Sixth International Symposium on Subtypes of Muscarinic Receptors) Life Sciences 11/12, 951-955.

1995 DebBurman, SK, & MM Hosey. Role of Protein Phosphorylation in the Desensitization of Muscarinic Cholinergic Receptors, in Molecular Mechanisms of Muscarinic Acetylcholine Receptor Function (Editor: J. Wess), R.G. Landes Company, Biomedical Publishers, Austin, USA, 209-226.

1995 DebBurman, SK, Ptasienski, J, Boetticher, E., Lomasney, JW, Benovic, JL, & MM Hosey.  Lipid-mediated regulation of G protein-coupled receptor kinases GRK2 & GRK3. Journal of Biological Chemistry 270, 5742-5747.

1995 DebBurman, SK, Kunapuli, P, Benovic, JL, & MM Hosey. Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases. Molecular Pharmacology 47, 224-233.

Invited Talks
2008 Tips to Start and Sustain a Student-Centered Research at a Liberal Arts College
American Society of Cell Biology Meeting, San Francisco, CA

2008 The Job Search & Interview Process, Panelist
Northwestern University Directions Professional Development Conference, Evanston, IL

2008 The Job Search & Interview Process, Panelist
Preparing Future Faculty Workshop, Oakton Community College, IL

2008 Insight into Parkinson’s Disease From Yeast Models
Rush Medical College/Rush University

2008 The 21st Century College Professor: Teacher, Scholar, & Citizen
Rush Medical College/Rush University

2007 A Faculty Career At a Liberal Arts College
Careers in Pharmacology Workshop
Great Lakes Chapter-American Society of Pharmacology and Experimental Therapeutics meeting

2005  A Toxic Shape, A Tragic Consequence: Yeasts & Undergraduates Help Understand Parkinson’s Disease
Skidmore College

2005 “Modeling Parkinson Disease: Two Yeasts, Distinct Insights”
Loyola Stritch School of Medicine, IL

2005 “Mentoring Preparing Future Faculty Fellows in Biology at Lake Forest College”
Northwestern Feinberg School of Medicine

2005 “Careers: Teaching & research in a small liberal arts college”
Loyola Stritch School of Medicine, IL
 
2005 “Integrating Teaching, Scholarship, & Service to Strengthen Undergraduate Student Scholarship”
Pedagogies of Engagement, An American Association of Colleges & Universities (AACU) Meeting, Bethesda MD

2004 “Protein Misfolding & Neurodegeneration: Insights from Chaperones and Yeast”
Purdue University, West Lafayette, IN

2004 “Pedagogical Scholarship: Translating Philosophy Into Practice”
Purdue University, West Lafayette, IN

2004 “Insights into Prion Disease and Parkinson Disease from Chaperones & Yeasts”
University of Illinois at Chicago, IL

2004 “Probing Yeasts to Gain Insight Into Neurodegeneration Linked to Parkinson Disease”
Rosalind Franklin University/Chicago Medical School, IL

2004 “Protein Misfolding & Neurodegeneration: Insights from Chaperones and Yeast”
Purdue University, Calumet City, IN

2004 “A Career as a College Professor: The Specifics of How To Get To Where You Want To Be”
IAmerican Society of Pharmaceutical & Experimental Therapeutics (ASPET) Committee on Minorities Affairs, Annual Meeting of Experimental Biology, Washington, DC

2004 “Careers: Teaching & research in a small liberal arts college”
Northwestern University, IL

2002 “The Small Liberal Arts College: Is this for You?”
(Beyond Books Series panel discussion on Alternate Careers in Academia, Preparing Future Faculty Program), Northwestern University, IL
 
2000 “Combating Neurodegeneration”
Biology Department, Lake Forest College, IL

2000 “Combating Diseased Protein Shapes With Molecular Chaperones”
Biology Department, Grinnell College, IA

2000 “Deadly Protein Shapes In Human Disease”
Joint Sciences Department, Claremont Colleges, CA

1999 “Combating Diseased Protein Shapes With Molecular Chaperones”
Department of Biology, Macalester College, MN

1999 “Careers: Teaching & Research In A Small Liberal Arts College” (A Bio-Opportunities Workshop) Northwestern University Medical School, IL

1999 “Diseased Protein Shapes: Combating Them With Molecular Chaperones”
Department of Biology, Western Michigan University, MI

1999 “Combating Neurodegenerative Diseases With Molecular Chaperones”
Faculty Seminar Series, Kalamazoo College, MI

1999 “Combating Neurodegenerative Diseases With Molecular Chaperones”
Department of Biology, Hope College, MI

1998 “Prions: Novel Agents Of Genetic Inheritance And Infectious Disease”
Pharmacia-Upjohn Company, Kalamazoo, MI

1998 "Molecular Chaperones & Mammalian Prion Formation"
BIOMEDICINE Meeting-American Federation of Medical Research, Washington DC

1998 "Prions: Agents Of Mad Cow Disease"
Department of Biology, Kalamazoo College, MI

1998 "Do Prions Cause Mad Cow Disease?"
Department of Biology, Alma College, MI

1997 "An Expanding World Of Prions"
NIH Rocky Mountain Laboratories, Hamilton, MT

1997 "Molecular Chaperones & Misfolded Proteins: Implications In Neurodegenerative Disease"
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, MD

1997 "Protein Conformation Switches: In Health & Disease"
Department of Biology, Wittenberg University, Springfield, OH

1997 "Mad Cow Disease: Can We Cure It?"
Department of Biology, Lake Forest College, IL

Other Talks
2002 “Experiential research projects promote learning an inquiry-based undergraduate science curriculum”
Undergraduate Research Network, National Council of Undergraduate Research, Whitewater, WI

1997 "Molecular chaperones modulate prion conformation switch"
Midwest Stress Response & Chaperones Conference, Chicago, IL

1996 "Phosphorylation and regulation of G protein-coupled receptors”
Department of Molecular Pharmacology & Biological Chemistry, Northwestern University Medical School, Chicago, IL

1995 "Lipid mediated regulation of G protein-coupled receptor kinases GRK2 and GRK3"
Graduate Research Symposium, Society for Neuroscience-Annual meeting of the Chicago Chapter, Chicago, IL

1995 "Molecular basis of homologous desensitization of G protein-coupled receptors"
Howard Hughes Medical Institute, University of Chicago, IL

1995 "G protein-coupled receptor regulation by protein phosphorylation"
Department of Biochemistry, Molecular Biology & Biochemistry, Northwestern University, IL

Posters (undergraduate co-authors asterisked)
2008 EUKARYON: The use of an undergraduate scholarship journal to strengthen inquiry-based pedagogy and a community of undergraduate scholars
S.K. DebBurman, *S. Davis, *M.  Fiske, P. Smith
American Society of Cell Biology Meeting, San Francisco, CA
 
2008 Investigation of Endosome/MVB Pathway-mediated Regulation of Alpha-Synuclein Localization, Accumulation, and Toxicity in a Yeast Model Reveals Unexpected Complexity
*A. Ayala, *M. White, S.K.DebBurman
American Society of Cell Biology Meeting, San Francisco, CA
 
2008Investigating Whether Alanine-76 and Serine Phosphorylation Contribute to Alpha-Synuclein Aggregation, Membrane Association, and Toxicity in Yeasts
*M. Fiske, *S. Valtierra, *S. Herrera, *M. White, *M. Zorniak, and S.K. DebBurman
American Society of Cell Biology Meeting, San Francisco, CA
 
2008 Evaluating Autophagic Regulation of a-Synuclein in a Budding Yeast Model
*R. Choi, *A. Konnikova, *J. McLain, *M. White, & S.K. DebBurman
American Society of Cell Biology Meeting, San Francisco, CA
 
2008 Yeasts Shed Light on a-Synuclein Hydrophobicity: Alanine-76 Regulates Aggregation & Plasma Membrane Binding
*M. Fiske, *S. Valtierra, *M.White, *M. Zorniak, and S.K. DebBurman 
American Society for Pharmacological & Experimental Therapeutics-Great Lakes Chapter Meeting
 
2008 Evaluating the Role of the Multi-Vesicular Body/Vacuole Pathway in the Regulation of a-Synuclein Aggregation and Toxicity in Budding Yeast
*A. Ayala, *M. Vahedi, *J. Price, Shubhik DebBurman
American Society for Pharmacological & Experimental Therapeutics-Great Lakes Chapter Meeting
 
2008 Similarities and Differences in a-Synuclein Properties Within Two Yeast Models: Analysis of E46K, A76E, & Post-Translation Modification Mutants
*. Valtierra, *M.White, *M. Fiske, *S. Herrera, & S.K. DebBurman
Chicago Signal Transduction Symposium
 
2008 S. Valtierra, M.White, M. Zorniak, M. Fiske, S. Herrera, & S.K. DebBurman
Evaluating a-Synuclein Concentration Threshold and Phospholipid Composition to Induce Aggregation, Membrane Localization and Toxicity in Yeast
*L. Kukreja, *S. Valtierra, S.K. DebBurman
Chicago Signal Transduction Symposium
 
2008 Similarities and Differences in a-Synuclein Properties Within Two Yeast Models: Analysis of E46K, A76E, & Post-Translation Modification Mutants
*S. Valtierra, *M.White, *M. Fiske, *S. Herrera, & S.K. DebBurman
Chicago Society for Neuroscience Symposium
 
2008 Evaluating the Role of the Multi-Vesicular Body/Vacuole Pathway in the Regulation of a-Synuclein Aggregation and Toxicity in Budding Yeast
*A. Ayala, *M. Vahedi, *J. Price, Shubhik DebBurman
Chicago Society for Neuroscience Symposium
 
2007 Evaluation of E46K & A76E a-Synuclein Aggregation and Toxicity In Budding & Fission Yeasts
*S. Valtierra, *M.White, *M. Zorniak, *S. Herrera, *M. Fiske, & S.K. DebBurman
American Society of Cell Biology Meeting, Washington DC
 
2007 Evaluating a-Synuclein Concentration Threshold and Phospholipid Composition to Induce Aggregation, Membrane Localization and Toxicity in Yeast
*L. Kukreja, *S. Valtierra, S.K. DebBurman
American Society of Cell Biology Meeting, Washington DC
 
2007 Evaluating the Role of the Multi-Vesicular Body/Vacuole Pathway in the Regulation of a-Synuclein Aggregation and Toxicity in Budding Yeast
*A. Ayala, *M. Vahedi, *J. Price, Shubhik DebBurman
American Society of Cell Biology Meeting, Washington DC

2007 Budding Yeast Model for Parkinson Disease
*M. White, *M.Zorniak, *L. Kukreja, *A. Ayala, *M. Fiske, S.K. DebBurman
Gordon Conference “Stress Proteins in Growth Development & Disease”, Oxford University, UK
         
2007 Fission Yeast Model for Parkinson Disease
S.K. DebBurman, *L. Kukreja, *K. Brandis, *M. Zorniak, *S. Valtierra
Gordon Conference “Stress Proteins in Growth Development & Disease”, Oxford University, UK

2007 Students As Scholars: Design of an Advanced Cell Biology Course Wherein Undergraduates Propose, Conduct, and Publish Original Research
S.K. DebBurman
Great Lakes Chapter-American Society of Pharmacology and Experimental Therapeutics meeting          

2007 EUKARYON: Design, Publication, and Governanance of a Student Peer-reviewed Undergraduate Journal of Life Science Scholarship at Lake Forest College
S.K. DebBurman, *M.Zorniak, *A. Spivak, *C. Bueter, *M. Mckinzey
Great Lakes Chapter-American Society of Pharmacology and Experimental Therapeutics meeting          

2007 The newest Familial Parkinson Disease Mutant E46K Alpha-Synuclein is Selectively Toxic to Yeast
*M.White, S.K. DebBurman
Great Lakes Chapter-American Society of Pharmacology and Experimental Therapeutics meeting

2007 In Parkinson Disease, What happens to Your Brain When Energy Generators Crash?
*M.Zorniak, S.K. DebBurman
Great Lakes Chapter-American Society of Pharmacology and Experimental Therapeutics meeting    

2007 a-SYNUCLEIN FISSION YEAST MODEL: Live Cell Evidence for Threshold Concentration for Aggregation
*L. Kukreja, *K. Brandis, S.K. DebBurman
Great Lakes Chapter-American Society of Pharmacology and Experimental Therapeutics meeting

2007 a-SYNUCLEIN FISSION YEAST MODEL: Live Cell Evidence for Threshold Concentration for Aggregation
*L. Kukreja, *K. Brandis, S.K. DebBurman
Chicago Signal Transduction Symposium

2007 The newest Familial Parkinson Disease Mutant E46K Alpha-Synuclein is Selectively Toxic to Yeast
*M.White, S.K. DebBurman
Chicago Signal Transduction Symposium

2007 EUKARYON: Design, Publication, and Governanance of a Student Peer-reviewed Undergraduate Journal of Life Science Scholarship at Lake Forest College
S.K. DebBurman, *M.Zorniak, *A. Spivak, *C. Bueter, *M. Mckinzey
Chicago Signal Transduction Symposium   

2007 The newest Familial Parkinson Disease Mutant E46K Alpha-Synuclein is Selectively Toxic to Yeast
*M.White, S.K. DebBurman  (SECOND PRIZE, undergraduate poster competition)
Chicago Society for Neuroscience Symposium (March 2007)
           
2007 a-SYNUCLEIN FISSION YEAST MODEL: Live Cell Evidence for Threshold Concentration for Aggregation
*L. Kukreja, *K. Brandis, S.K. DebBurman
Chicago Society for Neuroscience Symposium

2006 BUDDING YEAST MODEL FOR ALPHA-SYNUCLEIN: Evaluation of E46K toxicity, Catalase Deletion, & Multivesicular Body (MVB) formation.
*M. White, *M.Zorniak, *M. Vahedi, *S. Herrera, *K. Brandis, S.K. DebBurman
American Society of Cell Biology Meeting, San Francisco

2006 a-SYNUCLEIN FISSION YEAST MODEL: Live Cell Evidence for  Threshold Concentration for Aggregation
*L. Kukreja, *K. Brandis, S.K. DebBurman
American Society of Cell Biology Meeting, San Francisco

2006 Live Cell Evidence to Support Nucleation Polymerization Model for alpha-synuclein toxicity: Concentration is key.
*L. Kukreja, *K. Brandis, S.K. DebBurman
Poster, Chicago Society for Neuroscience Symposium

2005  Alpha-SYNUCLEIN FISSION YEAST MODEL: Concentration-Dependent Aggregation Without Membrane Localization or Toxicity”
*K. Brandis, *I. Holmes, *S. England, *N. Sharma, S.K. DebBurman American Society of Cell Biology Meeting, San Francisco, CA

2005 “Alpha-SYNUCLEIN BUDDING YEAST MODEL: Toxicity Enhanced By Impaired Proteasome and Oxidative Stress”
*T. Vaidya, *K. Brandis, *S. Herrera, *N. Sharma, B. Johnson, S.K. DebBurman American Society of Cell Biology Meeting, San Francisco, CA

2005 “EUKARYON: An Undergraduate Journal of Life Science Scholarship at Lake Forest College”
*K. Brandis, *T. Vaidya, & S.K. DebBurman American Society of Cell Biology Meeting, San Francisco, CA

2005 “Design of a Cell Biology Course Wherein Undergraduates Propose, Conduct, and Publish Original Research”
American Society of Cell Biology Meeting, San Francisco, CA

2005 “Fission Yeast Recapitulate Alpha-Synuclein Misfolding”
*K. Brandis, *I. Holmes, *S. England, S.K. DebBurman Experimental Biology, San Diego, CA (Katrina Brandis received an ASBMB Travel Award to attend the meeting)

2005 “Budding Yeast Model for Alpha-Synuclein: Evaluating E46K Mutant, Post-translational Modification,  & Ubiquitin Conjugating Enzyme Specificity”
*S. Herrera, *N. Sharma, *B Johnson, *K. Brandis, *R. Shrestha, *M. Stevenson, S.K. DebBurman.
Experimental Biology, San Diego, CA
(Sara Herrera received an ASBMB Travel Award to attend the meeting)

2005 “Design of a Cell Biology Course Wherein Undergraduates Propose, Conduct, and Publish Original Research” Experimental Biology, San Diego, CA

2005 “Fission Yeast Recapitulate Alpha-Synuclein Misfolding”
*K. Brandis, *I. Holmes, *S. England, S.K. DebBurman Chicago Signal Trandsuction Symposium, IL

2005 “Budding Yeast Model for Alpha-Synuclein: Evaluating E46K Mutant, Post-translational Modification,  & Ubiquitin Conjugating Enzyme Specificity”
*S. Herrera, *N. Sharma, *B. Johnson, *K. Brandis, *R. Shrestha, *M. Stevenson, S.K. DebBurman. Chicago Signal Trandsuction Symposium, IL

2005 “EUKARYON: A Undergraduate Journal of Life Science Scholarship at Lake Forest College”
*T. Vaidya, S.K. DebBurman. Chicago Signal Trandsuction Symposium, IL